Determination of concentrations of biological substances using raman spectroscopy and artificial neural networks discriminator

Author(s): Cohen, G.M. | Ham, F.H. |

Year: 1996

Citation: Patent number: 5553616 Issue date: Sep 10, 1996

Abstract: The concentration of a substance, such as glucose, in a biological sample, such as human tissue (e.g. the skin of an index finger) is non-invasively determined by directing the output beam of a laser diode onto and into the skin so as to cause Raman scattering. The output of a charge coupled device, upon which the scattered light is spatially dispersed according to frequency is digitized and applied to a processor. The processor compares the Raman scattering intensity characteristics of the sample with a comparative model, in particular, an artificial neural network discriminator (ANND). The ANND is trained with a plurality of Raman spectral characteristics from biological fluids or tissue, possessing known Raman scattered light intensities versus wavelength characteristics at known concentrations. A preferred implementation of the ANND employs fuzzy adaptive resonance theory-mapping (ARTMAP), which has robust noise rejection capabilities and can readily handle nonlinear phenomena.

Topics: Machine Learning, Applications: Biological Classification, Models: ARTMAP,

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